SESAMIN AND SESAMIN COMBINED WITH ALPHA-TOCOPHEROL IMPROVE AGE-RELATED KIDNEY DYSFUNCTION
نویسندگان
چکیده
منابع مشابه
Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction
Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. Sesamin, the bioactive compound extracted from Sesamum indicum, is a natural compound that has diverse beneficial effects on hypoglycemia and reducing cholesterol. The aim of this study is t...
متن کاملAntihypertensive effect of sesamin. IV. Inhibition of vascular superoxide production by sesamin.
We previously demonstrated the preventive effect of sesamin, a lignan from sesame oil, on the development of several experimental models of hypertension. In the present study, we explored the mechanisms underlying the antihypertensive effect of sesamin using the deoxycorticosterone acetate (DOCA)-salt rat hypertensive model. After a 5-week treatment period, aortic superoxide (O2-) production wa...
متن کاملSesamin inhibits lysophosphatidylcholine acyltransferase in Mortierella alpina.
The filamentous fungus, Mortierella alpina, accumulates complex lipids relatively rich in arachidonic acid (C(20:4) Delta(5,8,11,14)). The lignan, sesamin, has been used to reduce arachidonic acid production by specifically inhibiting Delta(5)-desaturation [Shimizu, Akimoto, Shinmen, Kawashima, Sugano and Yamada (1991) Lipids 26, 512-516]. Microsomal membrane preparations from M. alpina exhibit...
متن کاملAntihypertensive effects of sesamin in humans.
Sesamin, one of the lignans contained in sesame, has been considered to have medicinal effects. It has been reported that sesamin suppressed the development of hypertension in rats. In this study, using a double-blind, cross-over, placebo-controlled trial, we investigated the effect of 4-wk administration of sesamin on blood pressure (BP) in mildly hypertensive humans. Twenty-five middle-aged s...
متن کاملSesamin enhances cholesterol efflux in RAW264.7 macrophages.
Foam cells formation as a result of the uncontrolled cytophagy of modified cholesterol by macrophages plays a key role in the occurrence and development of atherosclerosis. Sesamin is an active constituent of Sesamum indicum which has been shown to possess multiple pharmacological activities. In this work, we investigated the effects of sesamin on foam cell formation and cholesterol efflux in R...
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ژورنال
عنوان ژورنال: Innovation in Aging
سال: 2017
ISSN: 2399-5300
DOI: 10.1093/geroni/igx004.1635